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).82,eighty three Sufferers with MBL with mutated motorists Have got a shorter the perfect time to first therapy in comparison with situations without the need of mutations. Once CLL is established, the growth dynamics of tumor cells is heterogeneous. Some patients exhibit a logistic-like actions through which the clone stabilizes after some time, While some Other folks display an exponential- like advancement sample.84 This exponential expansion, clinically described as “quick lymphocyte doubling time” remains regarded an adverse prognostic parameter in CLL.
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